Journal article
Resistance to first-line antibiotic therapy among patients with uncomplicated acute cystitis in Melbourne, Australia: Prevalence, predictors and clinical impact
SJ Curtis, JC Kwong, YL Chaung, D Mazza, CJ Walsh, KY Chua, AJ Stewardson
Jac Antimicrobial Resistance | Published : 2024
Abstract
Background: Australian guidelines recommend trimethoprim or nitrofurantoin as first-line agents for uncomplicated urinary tract infections (UTIs). Laboratory surveillance indicates high rates of trimethoprim resistance among urinary bacterial isolates, but there are scant local clinical data about risk factors and impact of trimethoprim resistance. Objectives: To determine the prevalence, risk factors, mechanism and impact of resistance to first-line antibiotic therapy for uncomplicated UTIs in the community setting. Methods: A prospective observational study from October 2019 to November 2021 in four general practices in Melbourne, Australia. Female adult patients prescribed an antibiotic f..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
This research was supported by internal funding and did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. A.J.S. and J.C.K. are supported by Early Career Fellowships from the National Health and Medical Research Council (GNT1141398 and GNT1142613, respectively).